Adenovirus-Associated Virus Multiplication

Translation Control. Adenovirus Virus-associated Rna And

Recombinant Human Interferon-? Inhibits Adenovirus Multiplication

The susceptibility of adenovirus to the inhibitory effect of human interferons in vitro was investigated. We tested recombinant human interferons-c~2, -/~1 and -7 against adenovirus serotypes 1 and 5 (group C), 3 and 7a (group B), and a wild strain isolated from an acutely ill child who later died. Pretreatment of WISH cells with interferon-? for 24 h induced a dose-dependent inhibition of mult...

Biochemical Studies on Adenovirus Multiplication. v. Enzymes of Deoxyribonucleic Acid Synthesis in Cells Infected by Adenovirus and Vaccinia Virus.

The mechanism of viral DNA synthesis may be expected to depend on the particular virus in question, i.e. its size and composition, genetic potentiality, rate of multiplication, intracellular site of multiplication, etc. Several possible mechanisms can be envisioned for the biosynthesis of viral DNA: (a) the “DNAsynthesizing enayme”1 system of the host cell may be utilized without modification; ...

The relationship between cytopathic changes and virus multiplication in HeLa cells infected with adenovirus.

It has already been reported by several investigators that characteristic morphological features are seen in HeLa cells infected with adenoviruses either by means of electron microscopic studies or by light microscopy of stained preparation's (Harf ord, Hamlin, Parker and van Ravenswaay, 1956; Morgan, Howe, Rose and Moore, 1956; Kj ellen, Lagermalm, Svedmyr and Thorsson, 1955; Boye.r, Leuchtenb...

Influenza Virus Multiplication Cycle

Human MxA and mouse Mxl are interferon-induced proteins capable of inhibiting the multiplication of influenza virus. MxA protein is localized in the cytoplasm, whereas Mxl protein accumulates in the nucleus. Taking advantage of stably transfected cell lines that constitutively express either MxA or Mxl protein, we examined the steps at which these proteins block influenza A viruses. In infected...